Single-cell multiome analysis of lymphangioleiomyomatosis (LAM)
Updated January 10, 2025Single cell RNAseq and single nuclei ATAC-seq of lymphangioleiomyomatosis (LAM) lungs to construct gene regulatory network controlling the transcriptional program of LAM cells. In vivo and in vitro LAM models were used to identify molecular mechanisms mediating LAM cell pathogenesis. Integrative single cell omics analyses identified the activation of uterine specific HOX-PBX transcriptional programs in pulmonary LAMCORE cells.
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Analysis Portals
Project Label
Single-cell multiome analysis of lymphangioleiomyomatosis (LAM)Species
Homo sapiens
Sample Type
specimens
Anatomical Entity
Lung
Organ Part
Unspecified
Selected Cell Types
Unspecified
Disease Status (Specimen)
lung lymphangioleiomyomatosis
Disease Status (Donor)
lung lymphangioleiomyomatosis
Development Stage
Library Construction Method
Nucleic Acid Source
single nucleus
Paired End
falseAnalysis Protocol
22c1689f-28cc-4567-97f4-a257a2156378, 34e77c76-bff2-437c-93dc-24070d736ba4File Format
Cell Count Estimate
15.0kDonor Count
3